Opportunity Description:

Professors Robin Turner and James Piret invite applications for a full-time post-doctoral fellowship position available in the field of bioanalytical Raman microspectroscopy and Raman chemical imaging. We seek a highly qualified individual with a doctoral degree in chemistry or physics or engineering with an interest in developing process analytical technologies for cell therapy bioprocess applications. Essential qualifications include experience measuring and analyzing Raman spectra of live or fixed cultured cells using a commercial Raman microspectroscopy instrument and common multivariate chemometric methods (e.g., principal component analysis). Experience with MATLAB and LabVIEW software applications would be an asset.For over 20 years our group has been investigating and develop novel Raman spectroscopy methods to probe the status of stem cells, Chinese hamster ovary and other cultured cell lines, as well as T-cells and red blood cells). For the manufacturing of therapeutic proteins, Raman spectroscopy is already being used for industrial manufacturing on-line analysis of glucose, lactate and CHO cell concentrations, whereas we are developing this technology as a process analytical technology for the production of cells for therapy. The postdoctoral fellow will join a multidisciplinary team that is working on developing this technology in the context of producing T-cells for cancer therapy and pancreatic cells for the treatment of diabetes. We are funded by Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, and other sources.