C&EN Webinar

Analyzing Protein Developability and Stability at High-Throughput

Watch On Demand

DETAILS:

On-demand virtual event

TOPICS:

Analytical Chemistry
Biological & Medicinal Chemistry

Brought to you by:

Understanding the biophysical state, quality and properties of biopharmaceuticals is essential in product and process development. However, available material, time and resources are often limiting.

Dynamic light scattering (DLS) is an industry standard technique for protein formulation, particle sizing and stability studies. This webinar will illuminate how high-throughput DLS (HT-DLS), performed in low-volume microwell plates, is used to understand aggregation as well as colloidal and thermal stability of therapeutic protein candidates and formulations. Application examples include various studies of freeze-thaw, formulation buffer screening and thermal stability.

Key Learning Objectives:

  • Background and instrumentation for HT-DLS
  • How DLS is used to study aggregation under applied stresses
  • How DLS evaluates protein colloidal stability via second virial coefficient A2 and the diffusion interaction parameter kD.

Who Should Attend:

  • Biopharma product development scientists in need of automated methods for characterizing protein stability
  • Formulation lab managers seeking to improve productivity with high-throughput DLS instrumentation

Speakers

20230613glogespeaker.png

Felix Gloge, Ph.D.

Field Application Scientist, Wyatt Technology

20230613siegspeaker.png

Christian Sieg, Ph.D.

Application Scientist, Wyatt Technology

melissaomearamoderator.jpg

Melissa O'Meara

Forensic Science Consultant, C&EN Media Group

ACS Institute

Keep learning. Excel in your career.

Choose from more than 200 courses in seven different categories, taught by experts in the chemistry community, online and in person.